G. Ulm
1985
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0
Influential Citations
7
Citations
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Abstract
Pharmacotherapy of parkinsonian tremor continues to be less than satisfactory, despite the implementation of new therapeutic strategies, including β-receptor blockers. Prodipin (1-isopropyl-4,4-diphenylpiperidine hydrochloride), the precursor of budipine, had already been found superior (unpublished study, Elena Klinik, Kassel, 1977) in this respect in a large number of patients. But the drug had one big disadvantage, it was tolerated on i.v. injection only. Oral doses caused nausea and vomiting and were thus not feasible. We now have high hopes for the product which was further developed, budipine.