J. Kohli, D. Glock, L. Goldberg
May 1, 1986
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Influential Citations
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Journal
Journal of Pharmacy and Pharmacology
Abstract
Antagonist activity of bulbocapnine on DA1 versus DA2 dopamine receptors was studied simultaneously in a dog under pentobarbitone anaesthesia and without phenoxy‐benzamine pretreatment. Fenoldopam (SK&F 82526) injected into the renal artery was the DA1 agonist and dipropyl dopamine or piribedil injected into the femoral artery were the DA2 agonists. Both at 0.5 and 1 mg kg−1 doses intravenous bulbocapnine caused nearly equal inhibition of DA1 and DA2 dopamine receptor‐mediated responses. Our results show that under these experimental conditions bulbocapnine is not a selective DA1 dopamine antagonist.