T. Pugsley, W. Lippmann
Oct 1, 1974
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0
Influential Citations
11
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Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
Butriptyline, a tricyclic compound (40 mg kg−1, i.p.), in contrast to the tricyclic desipramine (20 mg kg−1, i.p.), did not alter the accumulation or metabolism in areas of the rat brain of intraventricularly‐injected [3H]noradrenaline. It did not appreciably inhibit the displacement of 5‐HT by α‐ethyl‐3‐hydroxy‐4‐methyl phenethylamine in comparison with the tricyclic chlorimipramine. Butriptyline potentiated central 5‐HTP effects only slightly whereas chlorimipramine displayed a strong potentiation. It is concluded that butriptyline differs significantly from desipramine, as no inhibitory effect on brain noradrenaline uptake was found, and from chlorimipramine, as only a weak inhibitory activity on brain 5‐HT uptake was observed.