Y. Sakamoto, J. Matsukawa, Y. Hommura
1977
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Quality indicators
Journal
Nihon Kikan Shokudoka Gakkai Kaiho
Abstract
The effect of butropium bromide, which is a synthetic anti-cholinergic drug and used as premedication mainly for depression of salivation inhibiting the endoscopic examination, was researched by the double blind controlled method.Among 50 subjects, 25 cases were given butropium bromide (B.B. group) and the rest 25 were given a placebo.(placebo group).They were examined on 4 items, i. e., the reflexion depressing effect, the secretion depressing effect, the movement depressing effect, and the antalgic effect.On the test of the reflesion depressing effect, the effective ratio was 64% in both groups and no significant difference was obtained.The effective ratio of the secretion depressing effect was 80% in the B.B. group and 36% in the placebo group. A significant difference was observed with a level of P<0.005.The effective ratio of the movement depressing effect was 60% in the B.B. group and 36% in the placebo one: the difference was observed with a level of P<0.1.The effective ratio of the antalgic effect was 60% in the B.B. group and 32% in the placebo one; the significant difference was at a level of P<0.05.As side effects, 2 cases in the B.B. group showed nausea, etc., but they were slight.It was concluded that butropium bromide given as a premedicament for endoscopic examination was particularly effective on depression of secretion, and was very useful.