D. L. Morris, N. Goldschlager
Jun 17, 1983
Citations
0
Influential Citations
43
Citations
Quality indicators
Journal
JAMA
Abstract
VERAPAMIL hydrochloride has been shown to be useful in the treatment of symptomatic hypertrophic cardiomyopathy by decreasing left ventricular outflow obstruction, reducing left ventricular muscle mass, and increasing left ventricular diastolic compliance.1-4Verapamil-related hemodynamic and electrophysiological complications in these cases have been documented in those with high pulmonary capillary wedge pressures in the presence of left ventricular outflow obstruction, evidence of congestive heart failure, substantive atrioventricular nodal dysfunction, and hypotension.3Although clinical experience suggests that calcium may be effective in reversing the adverse effects of verapamil, such therapy has not been widely publicized.4-8We report a case of a patient with hypotension and profound bradycardia caused by verapamil therapy for hypertrophic cardiomyopathy, which responded well to calcium chloride. Report of a Case A 56-year-old woman with echocardiographic diagnosis of hypertrophic cardiomyopathy, asymmetric septal hypertrophy, and systolic anterior motion of the mitral valve was admitted to San Francisco