G. A. Dolinskii, S. Fedchenko, S. Mamontov
May 1, 1993
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Quality indicators
Journal
Bulletin of Experimental Biology and Medicine
Abstract
Recent years have seen an increasing number of applied studies on the use of pantothenic acid (the vitamin component of coenzyme A) and its analogs in various areas of medicine [4]. In a number of studies, evidence has been obtained that pantothenates afford protection to epithelial tissues, in particular by accelerating wound healing [7, 11, 141 and by preventing damage to the gastric and intestinal mucosas in radiation sickness [2]. Epithelial ulceration in the upper gastrointestinal tract due to a deficiency of this vitamin has also been reported [12, 15], as have been beneficial clinical effects of pantothenate-containing drugs in gastrointestinal ulcers [6, 10]. However, the cellular mechanisms underlying these effects have not been fully elucidated. This study was under t aken to test calcium pantothenate for its impact on cell proliferation in the gastric mucosal epithelium of rats.