J. B. Sokoudjou, Cyrille Ngoufack Tagousop, Afsar Khan
Oct 27, 2020
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Journal
Natural Product Research
Abstract
Abstract One new tirucallane triterpene named as canarimoic acid (1), and three known analogues: 3β-hydroxytirucalla-8,24-dien-21-oic acid (2), 3α-acetyltirucalla-8,24-diene-21oic acid (3) and 3-oxotirucalla-8,24-dien-21-oic (4) were isolated from the hydro-ethanolic crude extract of Canarium schweinfurthii. Their structures were established by extensive analysis of 1 D and 2 D NMR data in conjunction with mass spectrometry and by comparison with those reported in the literature. The evaluation of their antisalmonellal activity using broth microdilution method showed that compound 3 was the most active (MIC =16 µg/mL) against Salmonella Typhi and Salmonella Typhimurium followed by compound 1 (MIC= 32 µg/mL) against Salmonella Typhi and Salmonella Enteritidis. Graphical Abstract