Li Wang, Y. Zhi
Sep 28, 2021
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Quality indicators
Journal
Archives of Medical Science
Abstract
Recently, scientists have tried to increase organic chemistry productions for the treatment of many cancers such as ovarian cancers. In this regard, antioxidant molecules have a special place in the treatment of several cancers. In this work, it is find the inhibition effect of 2′-Hydroxy-5′-methoxyacetophenone on aldose reductase, alpha amylase, and also collagenase enzymes. Also, molecular modeling calculations were performed from comparing the biochemical activity of the 2′-Hydroxy-5′-methoxyacetophenone molecule with these enzymes.The enzymes used in these calculations are Aldose reductase (AR), Alpha Amylase (Alpha-Amy), and Collagenase from Clostridium histolyticum (Coll), respectively. After the docking calculations were performed, ADME/T analysis parameters were examined in order to calculate the properties of the methoxyacetophenone molecule to be utilized as a drug in the future. For determining of anti-ovarian cancer properties of 2′-Hydroxy-5′-methoxyacetophenone, MTT assay was used on normal (HUVECs), PA-1, Caov-3, and SK-OV-3 cell lines.2′-Hydroxy-5′-methoxyacetophenone also revealed significant cytotoxic activities against common ovarian cancer cell lines i.e., PA-1, Caov-3, and SK-OV-3. The IC50 values of 2′-Hydroxy-5′-methoxyacetophenone against PA-1, Caov-3, and SK-OV-3 cell lines were found 271, 326 and 405 µg/mL, respectively.As mentioned, the 2′-Hydroxy-5′-methoxyacetophenone had significant antioxidant and anti-ovarian cancer properties. It appears that the anti-ovarian cancer effect of 2′-Hydroxy-5′-methoxyacetophenone is due to their antioxidant effects.