A. Casy, G. H. Dewar
Jul 1, 1994
Citations
0
Influential Citations
9
Citations
Journal
Journal of pharmaceutical and biomedical analysis
Abstract
The 400 MHz 1H NMR spectrum of captopril in a variety of solvents is analysed and compared with those of epicaptopril and its disulphide analogue. A method for detecting isomeric and oxidative impurities by examination of a 1H NMR spectrum of captopril in DMSO-d6 is proposed. 13C NMR and MS data enable differentiation of captopril from its disulphide analogue but not from its diastereoisomer epicaptopril.