Marc Rodriguez, A. Heitz, Jean Martinez
1990
Citations
0
Influential Citations
25
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A synthesis of Boc- L -Leu-…(CH 2 -CH 2 )- L -Phe-OH and Boc- L -Leu-…(CH 2 -CH 2 )- D Phe-OH from Boc-βhomo- L -leucinal, through a Horner-Emmons reaction with ethyl 2-(diethylphosphono)-3-phenylpropionate is described. Intermediate cyclisation into lactames (3S,6R)-3-benzyl 6-isobutyl-piperidin-2-one and (3R,6R)-3-benzyl 6-isobutyl-piperidin-2-one allowed a facile and unambiguous identification of diastereomers.