Arun K. Ghosh, M. Brindisi
Jan 7, 2015
Citations
4
Influential Citations
418
Citations
Quality indicators
Journal
Journal of Medicinal Chemistry
Abstract
The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry.