M. L. Bender, G. Buist
Aug 1, 1958
Citations
0
Influential Citations
7
Citations
Journal
Journal of the American Chemical Society
Abstract
pared from sodlum acetate-1-C14. The kinetics of hydrolysis of the unlabeled compound in 60% dioxane--40% water were determined. The kinetic isotope effect in the hydrolysis of 2-chloro-2-methylpropane-2-C14 was determined by radioassay of the hydrolysis product, 2-methyl-2 derivative) at various fractions of reaction. The kinetic isotope effect (k12k14 was found to be 1.027 plus or minus 0.015. This kinetic isotope effect in an Sn1 (two-center reaction) is less than the kinetic isotope effects found in a number of Sn2 (three-center reactions) involving methyl these kinetic isotope effects probably reflect differences in the leaving groups as well as differences in the mechanisms of the processes.