I. Ekhato, J. K. Rinehart
Jun 15, 2011
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
4-Bromobenzoic acid [carboxyl-14C] and 4-(2-bromoacetyl) [Ar-13C6]benzonitrile were transformed into the title compounds containing [ring14C-thiazol-4-yl] and [Ar-13C6-benzonitrile]. 14C-Ravuconazole was prepared in 37% yield and Purity >99%. 13C6-Ravuconazole was made in 56% overall yield and Purity of >98%. Each labeled compound was converted by additional reaction steps to the corresponding labeled prodrug. Copyright © 2011 John Wiley & Sons, Ltd