H. Lebel
Apr 22, 2013
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Abstract
(Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 2,2,2-trichloroethyl ester) [66065-85-8] C7H6Cl3NO5 (MW 290.49) InChI = 1S/C7H6Cl3NO5/c8-7(9,10)3-15-6(14)16-11-4(12)1-2-5(11)13/h1-3H2 InChIKey = WBZXNGAFYBGQFE-UHFFFAOYSA-N (reagent for the selective Troc-protection of amino groups, namely for amino acids) Alternate Names: Succinimidyl 2,2,2-trichloroethyl carbonate; Trichloroethyl succinimidyl carbonate; Troc-OSu. Physical Data: mp 111–113 °C.1, 2 Solubility: soluble in dioxane, THF, DMF, CH2Cl2, alcohols, and most common organic solvents. Form Supplied in: white solid; widely available. Purification: recrystallization from petroleum ether.2 Preparative Method: the title reagent can be prepared from trichloroethyl chloroformate2, 3 or from trichloroethanol and disuccinimido carbonate.4 Handling, Storage, and Precautions: hygroscopic. Store dry.