Masanori Shigeno, Kazuya Hanasaka, Keita Sasaki
Mar 1, 2019
Citations
0
Influential Citations
20
Citations
Journal
Chemistry
Abstract
We herein demonstrate that the combination of LiO-tBu, CsF, and [18]crown-6 efficiently promotes the direct C-H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives). A variety of functional groups, including methyl, methoxy, halo, cyano, amide, and keto moieties, are compatible with this system. The reaction proceeds via the formation of a tert-butyl carbonate species.