J. Miller, E. Miller, G. Finger
1953
Citations
0
Influential Citations
33
Citations
Quality indicators
Journal
Cancer research
Abstract
Summary In an investigation on the importance of the ring positions of 4-dimethylaminoazobenzene to its carcinogenic activity, the following new compounds were synthesized and tested in the rat: 2-fluoro-, 2′,4′-difluoro-, 2′,5′-difluoro-, 3′,5′-difluoro-, and 2′,4′,6′-trifluoro-4-dimethylaminoazobenzene. All these compounds were found to be more active liver carcinogens than the parent dye. The same finding had been made previously for the 2′-, 3′-, and 4′-fluoro derivatives. On the basis of these results it appears that no position on the prime ring of 4-dimethylaminoazobenzene is directly concerned in the carcinogenic process. The other ring remains to be investigated by this method. The results further suggest that the effects of systematic fluoro-substitution on the activities of other biologically active molecules could furnish strong evidence on which positions do or do not contribute directly to the activity in question.