W. Lijinsky, H. W. Taylor
Dec 1, 1978
Citations
0
Influential Citations
16
Citations
Quality indicators
Journal
Ecotoxicology and environmental safety
Abstract
It was suggested some years ago that t-oxidation of nitrosodi-n-propylamine might play a part in the carcinogenic action of this compound (Pour et aL, 1975). So far there has been no indication that this is so from the tests of two fl-oxidi::ed derivatives, nitrosobis(2-hydroxypropyl)amine and nitrosobis(2-oxypropyl)amine, in Syrian golden hamsters (Kr/iger et al., 1974; Pour et al., 1977), in which the tumorigenic response is quite different from that of nitrosodi-n-propylamine. We have carried out a comparative test of the parent compound and those two t-oxidized derivatives in Sprague-Dawley rats, together with the halogenated derivative nitrosobis(2-chloropropyl)amine. All four compounds were tested at approximately equimolar doses which were administered to the rats for a fixed period.