K. Dooley, J. Stavenuiter, J. Westra
Jul 1, 1988
Citations
0
Influential Citations
15
Citations
Quality indicators
Journal
Cancer letters
Abstract
2-Amino-5-phenylpyridine (2-APP) is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. Since this mutagen is structurally similar to the multipotent carcinogen, 4-aminobiphenyl (4-ABP), we compared their relative tumorigenic activity in the neonatal male B6C3F1 mouse. After determinations of the maximum tolerated dose (MTD), both aromatic amines were administered i.p. at 2 dose levels (MTD and MTD/2) on days 1, 8, 15 and 22 after birth. Groups were killed at 9 and 12 months and examined for histopathologic changes. No treatment-related neoplastic lesions were observed for 2-APP. In contrast, 4-ABP was strongly carcinogenic and induced a high incidence of multiple hepatocellular adenomas and carcinomas.