S. Mirvish, S. Salmas, Richard G. Runge
Oct 1, 1982
Citations
1
Influential Citations
10
Citations
Quality indicators
Journal
Journal of the National Cancer Institute
Abstract
Acetoxime was tested for carcinogenicity by chronic administration in the drinking water to male and female outbred MRC-Wistar rats. The dose of 1.0 g/liter was administered 5 days/week for 18 months (total dose, 6.2--7.0 g/rat). The test compound induced benign hepatocellular adenomas in 80% of the males but did not produce tumors in the females. This is the first report that oximes, which are fairly widely used in industry, are tumorigenic.