R. Tabakovic, I. Tabaković
Mar 15, 1999
Citations
0
Influential Citations
4
Citations
Journal
Reactive & Functional Polymers
Abstract
Abstract The condensation reaction of either 5-nitrofuran-2-aldehyde (NFA) or 5-nitrofuran-2-aldehyde diacetate (NFAD) with p-hydroxybenzalhydrazide (PHBH) gave nifuroxazide (NF), a drug used for the treatment of acute bacterial diarrhea, by catalysis with crosslinked poly(vinylpyridine)-supported acids (PVPHX). The product NF was obtained with high yield and purity. The effects of the counteranion, X−, in polymer catalyst (PVPHX) on the rate of the reaction were studied. It was found that the catalytic activity is increasing in order: I−>ClO4−, Cl−=Br−>TsO−. The effects of temperature and amount of catalyst on the reaction rate were discussed.