Steven A. Loskot, Jianjun Zhang, J. M. Langenhan
Nov 13, 2013
Citations
0
Influential Citations
14
Citations
Journal
The Journal of organic chemistry
Abstract
Neoglycosylations are increasingly being employed in the synthesis of natural products, drug candidates, glycopeptide mimics, oligosaccharide analogues, and other applications, but the efficiency of these reactions is usually limited by slow reaction times. Here, we show that aniline derivatives such as 2-amino-5-methoxybenzoic acid enhance the rate of acid-catalyzed neoglycosylation for a range of sugar substrates up to a factor of 32 relative to the uncatalyzed reaction.