E. Rafiee, S. Tangestaninejad, M. Habibi
2004
Citations
0
Influential Citations
6
Citations
Journal
Bulletin of The Korean Chemical Society
Abstract
The synthesis of mandelates is very important in organic chemistry. They are used in artificial flavorings and perfumes. They are also employed as precursors for synthesis of a number of medicines and pesticides. The repellent effect against mosquitoes of certain esters (methyl, ethyl, isopropyl, butyl, isobutyl and hexyl) of dl-mandelic acid has been reported by Morton and co-workers. Piper in reporting results of entomological tests in Canada, rated ethyl mandelate as one of the best repellents against mosquitoes and black flies. There are a few methods for preparation of mandelates in literature. Sulfuric acid, 2,2-dimethoxypropane and sulfuric acid, thionyl chloride, ferric sulfate, sodium hydrogen carbonate and TiO2/SO4 8 have been used as catalysts in direct esterification of mandelic acid with alcohols. However, some of these procedures are not entirely satisfactory and suffer from one or more of the following drawbacks such as corrosivity of the strong acids, tedious work up, low yields, long reaction times and side reactions such as carbonization, oxidation, etherification,