Changsheng Yao, Ting-Feng Lu, Chenxia Yu
Aug 1, 2014
Citations
0
Influential Citations
4
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A series of novel 7,9-dihydrothieno[3′,2′:5,6]pyrido[2,3-d]pyrimidine-4,6(3H,5H)-dione derivatives were synthesized efficiently via the catalyst-free reaction of aldehyde, ethyl 2,4-dioxotetrahydrothiophene-3-carboxylate, and 2,6-diaminopyrimidine-4(3H)-one through the sequence of deethoxycarbonylation and three-component condensation in aqueous media. This protocol featured mild reaction conditions, high yields, easy work-up, and environmentally friendly procedure.