Fuyao Zhang, E. Moher, Tony Y. Zhang
Apr 30, 2007
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
The catalytic preparation of bicyclo[3.1.0]hexane-2-one-6-carboxylic acid ethyl ester 1 is described by cyclopropanation of cyclopentenone using 1,1,3,3-tetramethylguanidine (TMG) as a catalyst in high yield and high diastereoselectivity. This process has been applied to an efficient synthesis of the important intermediate, β-hydroxyl cyclopentanone 2.