J. Rainier, S. Allwein, J. Cox
Jan 25, 2001
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0
Influential Citations
71
Citations
Quality indicators
Journal
The Journal of organic chemistry
Abstract
This paper describes a formal total synthesis of the marine ladder toxin hemibrevetoxin B from Danishefsky's dienes. This approach couples the generation of C-glycosides from cyclic enol ethers with metathesis or acid-mediated annulation reactions. The result is a highly efficient synthesis of the tetracyclic ring system of hemibrevetoxin B.