C. Wells, C. Ajmone‐Marsan, E. Frei
May 1, 1957
Citations
0
Influential Citations
30
Citations
Journal
Electroencephalography and clinical neurophysiology
Abstract
Abstract 6-Azauracil, a new experimental anti-tumor agent, has been given to 19 patients. In 17, it has induced significant electroencephalographic and neurologic changes. EEG changes have consisted of: abolition of the fast rhythms; disorganization of the background activity with moderate amplitude, irregular slowing; depression or disappearance of the response to photic stimulation; and appearance of high amplitude delta rhythm. Clinically, the most striking change has been lethargy progressing to subcoma. The discrepancy between the electrographic changes and the clinical abnormalities has been striking, the electrographic abnormalities generally appearing considerably before those detectable clinically. All manifestations induced by the 6-Azauracil have regressed when the drug was discontinued. The changes induced were directly related to the dosage of the drug employed. Children appeared more susceptible than adults to its toxic manifestations. Its mode and site of action are unknown.