Todd Teigeler, Heather Stahura, Rizwan Alimohammad
Aug 20, 2019
Citations
0
Influential Citations
12
Citations
Journal
Journal of Cardiovascular Electrophysiology
Abstract
Loperamide, an antidiarrheal agent, is a µ‐opioid receptor agonist increasingly abused to prevent opioid withdrawal or to produce euphoric effects. At supra‐therapeutic doses, loperamide can cause cardiac toxicity due to blockade of Na and IKr channels, resulting in wide QRS rhythms, severe bradycardia, prolonged QTc, polymorphic ventricular tachycardia, cardiac arrest, and death. There are limited data on the cardiotoxic effects of high dose loperamide.