R. Salvador, C. Atkins, S. Haber
Apr 1, 1970
Citations
0
Influential Citations
19
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The administration of chlorcyclizine or phenobarbital reduced the serum concentration of cholesterol, triglycerides and phospholipids in the male and female mouse and chlorcyclizine was more potent than phenobarbital. The reductions caused by chlorcyclizine administration in the mouse were not always associated with an accumulation of cholesterol or triglycerides in liver. Chlorcyclizine had little or no effect on the serum concentration of cholesterol and phospholipids in the rat, but the serum concentration of triglycerides was reduced markedly. The reduction of serum triglycerides in the chlorcyclizine-treated rat was not correlated with either an increase in liver weight or an increase in the concentration of triglycei ides in liver.