Zhang Qi-ai
2005
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Journal
Chinese Occupational Medicine
Abstract
Objective To explore functional and histological changes of testis in rats subchronically induced by methyl chloroacetate. Methods 55 male rats were divided into five groups, and ingested with methyl chloroacetate at the doses of ~0 (NS.) , 4.3,8.6,17.2,34.4 mg/kg respectively for 13 weeks. Histopathological changes of testis and epididymis were observed, and the rates of sperm motility and counting,sperm shape abnormality, the apoptosis of testicular cells and the level of testosterone(T) in serum were measured. Results The organ coefficient of testis, the level of T in serum and the apoptosis of testicular cells between the controls [0.80±0.09, (14.70±8.04)μg/L,(6.40±4.51)% respectively] and the highest group [0.85±0.05,(5.93±2.75)μg/L,(18.22±7.03)% respectively] were significantly different (P0.05). Conclusion The changes of testis tissue and testosterone level of serum in male rats were observed at the highest dose of methyl chloroacetate treatment.