W. Stott, B. Gollapudi
2001
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Abstract
Publisher Summary This chapter explores 1, 3-dichloropropene uses, hazards, short term assays. 1, 3-dichloropropene is a soil fumigant nematocide, for preplanting control of parasitic plant nematodes in numerous food and nonfood crops including deciduous fruit and nuts, vines, strawberries, field crops, vegetables, tobacco, tree nurseries, and numerous other specialty crops. 1, 3-dichloropropene is irritating to eyes and skin of animals. Assays employing mammalian cell lines have also resulted in mixed evidence of genotoxicity. Negative results have been obtained using an epoxidized soybean oil-stabilized mixed isomer formulation of 1, 3-dichloropropene in the Chinese hamster ovary (CHO). HGPRT forward mutation and rat hepatocyte unscheduled DNA synthesis assays. 1, 3-dichloropropene samples of unknown purity or stabilizing agent were negative in chromosomal aberration assays in CHO cells, and rat liver cell lines. 1, 3-dichloropropene has remains one of the few remaining compounds available to agriculture for fumigating soils to eliminate parasitic nematodes. This compound has been extensively evaluated in a number of test organisms for acute, subchronic and chronic toxicity, reproductive and developmental toxicity, carcinogenicity, and genotoxicity. Its metabolism in animals, including humans, has also been extensively studied and is relatively well understood.