W. Gui
2004
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Quality indicators
Journal
Chinese Journal of Clinical Pharmacology and Therapeutics
Abstract
AIM: To study the antihypertensive characteristics of iptakalim (Ipt) and pinacidil (Pin), the potassium channel openers (KCOs) of aliphatic amines and guanidine monohydrate, respectively. METHODS: The conscious noninvasive method with tail cuff was performed in rats to record the systolic blood pressure (SBP) and HR. RESULTS: SBP decreased and HR increased prominently in a dose dependent manner after treatment with Pin at the doses of 2.0 and 4.0 mg·kg -1 . While treated with Ipt at the doses of 2.0 , 4.0 and 8.0 mg·kg -1 under the same experimental conditions, SBP decreased but HR had no significant change. When administered with Ipt and Pin simultaneously, SBP decreased synergistically, and the effects on elevating HR were equal to that of Pin. CONCLUSION: Antihypertensive characteristics of Ipt are different from that of Pin, and the antihypertensive effects can be strengthened by combination of Pin and Ipt.