Iu R Mirzaev, I. T. Plotnikova, R. Shakirov
1993
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Journal
Eksperimental'naia i klinicheskaia farmakologiia
Abstract
The pharmacological studies of the steroidal alkaloid imperialone have revealed its high M-cholinolytic activity on the heart, which was accompanied by sensibilization of M-cholinoreceptors in the secretory cells of lacrimal, salivary, and gastric glands and M-receptors in the smooth muscle of the intestine and urinary bladder. Bearing in mind the currently available data on M-cholinoreceptors, imperialone can be regarded as M2-cholinolytics having M3- and M4-cholinopotentiating properties. Imperialone is a potent agent used for selective cardiac M2-receptor blockade and for enhancement of the functional activity of smooth muscle and secretory organs that have M3- or M4-cholinoreceptors.