P. Price, A. Otsuka, J. Poser
May 1, 1976
Citations
9
Influential Citations
690
Citations
Quality indicators
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abstract
A gamma-carboxyglutamic acid-containing protein has been purified from the calcified tissues of several vertebrates. The presence of three-gamma-carboxyglutamic acid residues in the bovine protein was established by alkaline hydrolysis and amino acid analysis, a method based upon studies with synthetic gamma-carboxyglutamic acid. The identity of gamma-carboxyglutamic acid in the bovine protein was established by mass spectroscopy on the unknown amino acid isolated from alkaline hydrolysates.