A. Pandey, P. Mali, D. Sachdeva
2011
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Influential Citations
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Journal
Journal of Pharmaceutical Research
Abstract
The aim of present study was to characterize best optimized Levobunolol HCl occusert formulations with special reference to glaucoma treatment, biologically. Levobunolol HCl occuserts were prepared using hydroxypropyl methylcellulose (HPMC, 3% & 4%), poly vinyl pyrrolidone (PVP, 1%), methyl cellulose (MC, 1% & 2%) as polymers by solvent casting technique with objectives of increasing contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy. Based on their physiochemical and invitro drug release characterization, formulations (F & F ) containing 4 % and 3 % HPMC were selected as best optimized formulations. Further, 2 1 these formulations were subjected to biological characterization such as microbial sterility testing, Modified Draize eye irritation and in-vivo drug release studies for their efficacy, reliability and clinical safety. Finally, accelerated stability testing (aging study) was also carried out. Results of these studies revealed that, occusert formulations (F & F ) passed the test for sterility, there was no irritation to the sensitive ocular tissues and 2 1