J. Fujisaki, Y. Tokunaga, T. Takahashi
Aug 1, 1996
Citations
0
Influential Citations
8
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
Disodium (fluorescein‐6−carbonyloxy)acetoaminomethylene bisphosphonate (CF‐BP), a prodrug of 6−carboxy‐fluorescein, is efficiently absorbed by the skeleton where it hydrolyses to carboxyfluorescein. An osteotropic drug‐delivery system based on this bisphosphonic prodrug has been developed as a novel method for site‐specific and controlled delivery of drugs to the bone. In this study the physicochemical properties of the prodrug have been characterized by investigating the affinity of CF‐BP for hydroxyapatite and the hydrolysis of the compound to carboxyfluorescein.