K. Kurata, C. Ashby, R. Oberlender
Dec 1, 1996
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Journal
Synapse
Abstract
In this study, we examined the effect of n‐methylquipazine (NMQ), which is a putative 5‐hydroxytryptamine, (5‐HT3) receptor agonist, on the extracellular concentrations of dopamine (DA) and one of its metabolites, dihydroxyphenylacetic acid (DOPAC), in the anterior medial prefrontal cortex (AmPFc) of awake, freely moving rats. The administration of NMQ via the perfusion fluid produced a concentration‐dependent (10‐1,000 μM) increase in extracellular DA levels in the AmPFc. In contrast, NMQ produced a decrease in the extracellular concentrations of DOPAC. The increase in extracellular DA levels returned to baseline after the removal of NMQ from the perfusate. The increase in extracellular DA levels in the AmPFc produced by 100 μM of NMQ was markedly attenuated by either the coadministration of tetrodotoxin (1 μM), which inhibits axonal impulse flow, or the depletion of extracellular Ca2+ by removing CaCl2 and adding EDTA to the perfusate.