Yutaka Inoue, K. Ito, T. Sakaue
Aug 1, 2004
Citations
0
Influential Citations
2
Citations
Journal
Clinical calcium
Abstract
Recently, we developed 2-(4- [4-nitrobenzyloxy] benzyl) thiazolidine-4-carboxylic acid ethyl ester (SN-6), a newly synthesized and selective inhibitor of Na(+)/Ca(2+) exchanger. SN-6 is a selective inhibitor for the Ca(2+) influx mode of Na(+)/Ca(2+) exchanger. And this compound attenuated hypoxia/reoxygenation-induced renal tubular cell damage and ischemia/reperfusion-induced renal failure. These results suggest that SN-6 is expected to be pharmacological tools to study the roles of the exchanger and a new anti-ischemic drug.