K. Venkatakrishnan, L. Moltke, S. Duan
Mar 1, 1998
Citations
3
Influential Citations
49
Citations
Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
The kinetics of the N‐demethylation of adinazolam to N‐desmethyladinazolam (NDMAD), and of NDMAD to didesmethyladinazolam (DDMAD), were studied with human liver microsomes using substrate concentrations in the range 10–1000 μm. The specific cytochrome P450 (CYP) isoforms mediating the biotransformations were identified using microsomes containing specific recombinant CYP isozymes expressed in human lympho‐blastoid cells, and by the use of CYP isoform‐selective chemical inhibitors.