F. Spreafico, A. Vecchi, A. Mantovani
Aug 1, 1975
Citations
0
Influential Citations
62
Citations
Quality indicators
Journal
European journal of cancer
Abstract
Abstract The immunostimulatory activity of tetramisole and its levo isomer levamisole, has been investigated in tumorous and non-tumorous experimental animals. These compounds were shown to raise the anti-SRBC response in normal and aged mice and to increase the incidence, severity and duration of allergic encephalomyelitis in rats. Treatments with levamisole were capable of increasing survival and inducing cures in L1210 leukemia-bearing mice when administered in conjunction with irradiated tumor cells. Increased anti-leukemia resistance to subsequent tumor challenges were also observed in animals primed with inactivated tumor cells and injected with levamisole. Single doses of these chemicals could also reduce the number of lung metastases in Lewis lung carcinoma bearing C57B1 6 mice whereas significant life-span prolongation and cures were seen in this system when these agents were employed in a combined chemoimmunotherapeutic approach.