T. Rahman, K. Khattak, W. Liaqat
Jun 1, 2015
Citations
1
Influential Citations
9
Citations
Quality indicators
Journal
Records of Natural Products
Abstract
The phytochemical examination of the extract of bark of Millettia ovalifolia yielded chemical constituents, which included one novel flavonoid 7-(4-methoxyphenyl)-9H-furo [2, 3-f] chromen-9-one and four new source compounds characterized as 3,7-Dihydroxy-2-phenyl-4H-chromen-4-one, (E)-Ethyl-13-(3,4dimethoxyphenyl)acrylate, (E)-Methyl-3-(3,4-dimethoxyphenyl)acrylate and N-Ethylacetamide. These compounds were characterized by using advance modern spectroscopic analytical techniques such as UV, IR, 1D, 2D NMR and mass spectrometry. The novel flavonoid (1) displayed significant inhibition of cytosolic form of bovine carbonic anhydrase-II with IC50 value of 17.86 ± 0.07 μM. This flavonoid may be used as a new pharmacophore to treat cystic fibrosis, glaucoma, epilepsy, leaukomia and other disorders such as neurology etc.