B. S. Balotro, P. Sabban
May 27, 2017
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Abstract
Background: Verapamil hydrochloride is a commonly prescribed drug in the management of hypertension, angina and cluster headache prophylaxis. Verapamil hydrochloride has a disadvantage of low bioavailability because of extensive hepatic metabolism (only 10% to 20% becomes bioavailable) and short half-life (2 to 4 hours). As a result, it requires frequent dosing of the drug leading to the problem of noncompliance in patients and alternating over and under doses of the drug. A method of circumventing hepatic first pass effect is by making the drug particle microsized (<10 μm) and lipophilic.