R. Lipnick
1986
Citations
4
Influential Citations
52
Citations
Journal
Trends in Pharmacological Sciences
Abstract
The year 1986 marked the 85th anniversary of the publication of Charles Ernest Overton’s classic monograph Studien uber die Narkose (‘Studies of Narcosis’) [1]. This book has been cited widely by scientists studying the correlation of biological activity with partition coefficients and the mechanism of anaesthesia. It is of enormous value to modern toxicologists, particularly those involved in the development of quantitative structure—toxicity relationships, and the predictive limitations of such models. Overton reported a wealth of precise physiological and histological observations on the response of a variety of plant and animal species to a large number of organic compounds. His remarkable deductions continue to serve as an inspiration for new scientific research and discovery.