O. Lafont, C. Cavé, S. Ménager
Feb 1, 1990
Citations
1
Influential Citations
10
Citations
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract Primidone is metabolized either into phenylethylmalondiamide or phenobarbital. 2-Hydroxyprimidone was synthesized and tested as a potential intermediate common to these two biodegradation pathways in dogs as well as in vitro. On the other hand, the mechanism of the formation of α-phenyl-γ-butyrolactone during intoxication was investigated and the role of precursor played by the phenobarbital generated in vivo was shown.