H. Suojalehto, K. Karvala, Katriina Ylinen
Sep 1, 2015
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Quality indicators
Journal
European Respiratory Journal
Abstract
3-(Bromomethyl)-2-chloro-4-(methylsulfonyl)- Benzoic acid powder has been produced periodically in a Finnish chemical factory since 2010. It is an intermediate product of a plant protective agent. We describe two cases with occupational respiratory diseases and urticaria related to that benzoic acid derivate; skin prick test results are presented in the table. To our knowledge, IgE-mediated sensitization or respiratory diseases related to this agent have not been reported earlier. Patient 1, a process manager, had rhinitis, sneezing, cough and dyspnea during the process periods since 2011. He also had urticaria in uncovered skin area after washing the reactor used in the process. Specific inhalation challenge (SIC) showed positive immediate bronchial reaction, FEV1 -17% combined with increase in exhaled nitric oxide and positive nasal reaction. In addition, open skin test was positive. He was diagnosed with occupational asthma, rhinitis and urticaria. Patient 2, a mechanic, had rhinitis, sneezing and urticaria related to the same process since 2013. Open skin test was positive, SIC was not performed. He was diagnosed with occupational urticaria and rhinitis. Conclusions: This benzoic acid derivate seems cause occupational asthma, rhinitis and urticaria via IgE-mediated mechanisms. An evaluation of the respiratory and skin symptoms of the exposed workers in the factory is ongoing.