J. Offer, P. Dawson
2000
Citations
0
Influential Citations
85
Citations
Quality indicators
Journal
Organic letters
Abstract
[reaction: see text] The selective formation of an amide bond in the presence of unprotected functional groups is a challenging problem of peptide chemistry. A 2-mercaptobenzyl group tethered at the N-terminus of model peptides was observed to facilitate amide bond formation when a peptide thioester was added under mild aqueous conditions.