G. I. Podzigun, N. G. Pashkurov, V. Reznik
Nov 1, 1980
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Journal
Bulletin of the Academy of Sciences of the USSR, Division of chemical science
Abstract
Conclusions1.2-Acylthiopyrimidines and 1-acyl-4,6-diamino-1,2-dihydro-2-pyrimidinethiones react with nucleophilic reagents to give 2-mercaptopyrimidines and the corresponding carboxylic acid derivatives.2.The 6-amino-4-acylamido-1H(3H)-dihydro-2-pyrimidinethiones are acylated by acyl halides either at the S atom or at the NH2 group, while their salts are alkylated by alkyl halides at the S atom.3.2-Acylthio-4,6-diaminopyrimidines and 1-acyl-4,6-diamino-1,2-dihydro-2-pyrimidinethiones are capable of rearranging to the isomeric acyl derivatives.