B. Karwowski, K. Seio, M. Sekine
Mar 1, 2007
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Journal
Journal of Heterocyclic Chemistry
Abstract
We describe basic chemical properties of 4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl (DECDO) in view of its use as a protecting group for the 2′-hydroxyl function of ribonucleosides. The DECDO group is found to be compatible with the DMTr strategy for the currently-used oligonucleotide synthesis. Post-synthetic treatment with ammonia results in the conversion of this protecting group into the 4,5-dicarbamoyl-1,3-dioxolan-2-yl (DCBDO) group which is unexpectedly more stable in aqueous acidic solution.