A. V. Bogat-skii, R. Ivanova, S. Andronati
Jul 1, 1981
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The alkaline hydrolysis, amidation, and methylation of 4,5-dihydropyrrolo[1,2,3-e,f][1,5]benzodiazepin-6(7H)-one derivatives under various conditions were investigated. The ionization constants (pKα) for 1,2-dimethyl-4,5-dihydro[1,2,3-e,f][1,5]benzodiazepin-6(7H)-one were calculated by the Hammett indicator method, and two values, viz., pKα1 = −2.37 and pKα2= 5.53, which were ascribed to protonation of the diazepine ring and the indole ring of the molecule, respectively, were obtained.