Paul S. Humphries, Quyen-Quyen T. Do, David M. Wilhite
May 27, 2009
Citations
0
Influential Citations
5
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 2-Amino-4-heteroarylpyrimidines were initially synthesized by microwave-induced S N Ar reactions of primary alkyl amines and 2-methylsulfonylpyrimidines or 2-chloropyrimidines. Following this methodology, pendant piperidine functionality was elaborated utilizing silica-bound reagents in microwave-assisted reductive amination and amide bond formation protocols. These methods proved to be versatile, efficient, and amenable to parallel synthesis.