B. S. Holla, Kanakamajalu Shridhara, M. Shivananda
Jun 1, 2002
Citations
0
Influential Citations
3
Citations
Journal
ChemInform
Abstract
Reactions of 3-aryloxymethyl-4-amino-5-mercapto-1 ,2,4-triazoles 1 with aromatic carboxylic acids, furoic acid, oxalic acid, monoch10roacetic acid and phenacyl bromide furnish various N-bridged heterocycles viz., triazolothiadiazoles, bis triazolothiadiazoles, triazolothiadiazinones and triazolothiadiazines . The structures of these N-bridged heterocycles are characterized on the basis of elemental analyses, IR, NMR and mass spectral data. Some of these compounds are also subjected to antibacterial screening studies. The pharmacological importance of nitrogen bridged heterocycles derived from 1,2,4-triazoles paved the way towards active research in triazole chemistry. As a result, variety of new compounds were being added to this field every year. A number of attempts were made to improve the activity of these compounds by varying the substituents on the triazole nucleus. The literature survey reveals that many N-bridged heterocycles such as triazolothiadiazoles , triazolothiadiazinones and tria zolothiadiazines derived from 1,2,4-triazoles display broad spectrum of biological activities l • 15